Action of steroids and plant triterpenoids on CatSper Ca2+ channels in human sperm.

@article{Brenker2018ActionOS,
  title={Action of steroids and plant triterpenoids on CatSper Ca2+ channels in human sperm.},
  author={Christoph Brenker and Christian Schiffer and Isabel Viola Wagner and F T{\"u}ttelmann and Albrecht Roepke and Andreas Rennhack and Ulrich Benjamin Kaupp and Timo Str{\"u}nker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2018},
  volume={115 3},
  pages={
          E344-E346
        }
}
The sperm-specific Ca channel CatSper (cation channel of sperm) controls the intracellular Ca concentration and, thereby, the swimming behavior of sperm. Human CatSper is activated by progesterone (1, 2), an oviductal hormone, which stimulates Ca influx and motility responses. By patch-clamp recording from human sperm, Mannowetz et al. (3) studied the action of the steroids pregnenolone sulfate (pregS), testosterone, hydrocortisone, and 17-β-estradiol (estradiol) as well as that of the plant… CONTINUE READING

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