Action of some retinol derivatives and their provitamins on microsome-catalyzed formation of benzo[a]pyrene-DNA adduct.

  title={Action of some retinol derivatives and their provitamins on microsome-catalyzed formation of benzo[a]pyrene-DNA adduct.},
  author={Girish M. Shah and Umesh C. Goswami and R. K. Bhattacharya},
  journal={Journal of biochemical toxicology},
  volume={7 3},
Several vitamin A compounds have been tested for their ability to suppress formation of DNA adduct by the carcinogen benzo[a]pyrene (B[a]P) in an in vitro reaction catalyzed by rat liver microsomes. Retinol, retinal, 3-dehydroretinol and 3-hydroxyretinol were found to be effective inhibitors of adduct formation. Certain carotenoids that are precursors of these retinoids also displayed considerable inhibitory capacity. Carotenoids and the 3-substituted retinoids appeared to modulate the DNA… 

Effects of carotenoid-rich food extracts on the development of preneoplastic lesions in rat liver and on in vivo and in vitro antioxidant status.

Carotenoid-rich extracts of these three foods substantially inhibited biochemical and cellular events thought to play a role in the early stages of hepatocarcinogenesis.

Discovery and biological relevance of 3,4-didehydroretinol (vitamin A2) in small indigenous fish species and its potential as a dietary source for addressing vitamin A deficiency

The vast potential of production and consumption of DROL-rich SIS in food-based strategies to combat VAD in Bangladesh and other developing countries with high prevalence of VAD is highlighted.

Chemoprevention of lung cancer: the rise and demise of beta-carotene.

  • G. Omenn
  • Medicine
    Annual review of public health
  • 1998
Beta-carotene and retinoids were the most promising agents against common cancers when the National Cancer Institute mounted a substantial program of population-based trials in the early 1980s. Both

Functioning of Lycopene in Mammalian System: A Review

Preliminary research suggests that lycopene may reduce the risk of macular degenerative disease, serum lipid oxidation and cancer of the lung, bladder, cervix and skin.

In Vitro Differentiation of an Epithelial Stem Cell Line Derived from the Fetal Syrian Hamster Lung

The developmental process includes various cellular and molecular events which are relevant to the regeneration of mature respiratory epithelium, and the likelihood is high that in the adult respiratory epithelial tissue there is a population of undifferentiated pluripotent stem cells.

The Respiratory System

The primary function of the respiratory system is to transport air into and out of the lungs so that oxygen can be exchanged for carbon dioxide. The upper respiratory system includes the nose, nasal



Inhibition in vivo of the formation of adducts between metabolites of benzo(a)pyrene and DNA by butylated hydroxyanisole.

BHA appears to inhibit BP-induced pulmonary adenoma formation by inhibiting the amount of the BPDE:DNA adducts formed in lung, and possible mechanisms by which BHA treatment inhibits the formation of BPDe:DNAAdducts are discussed.

Effects of retinoids on metabolizing enzymes and on binding of benzo(a)pyrene to rat tissue DNA.

Retinoids, by altering the metabolism of carcinogens, could influence the initiation stage of carcinogenesis and reduce in vivo binding of benzo(a)pyrene to rat liver DNA.

Mechanism of the in vitro antimutagenic action of retinol.

It is concluded that retinoids suppress the mutagenicity of aminoimidazoazaarenes and this is achieved through inhibition of their cytochrome P450-dependent metabolic activation.

Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids.

Myricetin, robinetin and luteolin inhibited the mutagenic activity resulting from the metabolic activation of benzo[a]-pyrene and (+/-)-trans-7,8-dihydroxy-7-8-catechin, genistein, kaempferide and chrysin by rat liver microsomes.

Inhibition of epidermal metabolism and DNA-binding of benzo[a]pyrene by ellagic acid.

Binding of [3H]benzo(a)pyrene to natural and synthetic nucleic acids in a subcellular microsomal system.

The results provide the first evidence that the microsomal-mediated binding of [3H]BP to nucleic acids is not just due to tritium exchange, and a derivative of the hydrocarbon is covalently bound to the nucleic acid, and not simply intercalated.