Action of some bisquaternary derivatives of phthalic acids and related substances on neuromuscular transmission

@article{Danilov1972ActionOS,
  title={Action of some bisquaternary derivatives of phthalic acids and related substances on neuromuscular transmission},
  author={A. Danilov and I. J. Kvitko and V. V. Lavrentieva and M. J. Michelson and B. A. Porai-Koshits and E. Rozhkova and S. Shelkovnikov},
  journal={British Journal of Pharmacology},
  year={1972},
  volume={44}
}
  • A. Danilov, I. J. Kvitko, +4 authors S. Shelkovnikov
  • Published 1972
  • Chemistry, Medicine
  • British Journal of Pharmacology
  • 1 All the bisquaternary derivatives of terephthalic acid with three methyl groups on each nitrogen atom (PK‐107, PK‐95, PK‐97 and PK‐126) were depolarizing neuromuscular blocking agents. The most active was the compound PK‐97, in which the two quaternary groups are separated by sixteen atoms and are about 20 Å (2 nm) apart. Activity was reduced many fold either by decreasing the separation to twelve atoms or by increasing it to eighteen atoms. It was also reduced several hundred fold when one… CONTINUE READING
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