Action of pyrazolopyridines as modulators of [3H]flunitrazepam binding to the gaba/benzodiazepine receptor complex of the cerebellum.

@article{Supavilai1981ActionOP,
  title={Action of pyrazolopyridines as modulators of [3H]flunitrazepam binding to the gaba/benzodiazepine receptor complex of the cerebellum.},
  author={P. Supavilai and M. Karobath},
  journal={European journal of pharmacology},
  year={1981},
  volume={70 2},
  pages={
          183-93
        }
}
  • P. Supavilai, M. Karobath
  • Published 1981
  • Chemistry, Medicine
  • European journal of pharmacology
  • The pyrazolopyridines etazolate (SQ 20009) and cartazolate (SQ 65396) have strong modulatory effects on the GABA/benzodiazepine receptor complex of rate cerebellum. Thus, etazolate and cartazolate directly stimulate [3H]flunitrazepam binding (with EC50 values of 1.2 microM and 0.3 microM respectively) by increasing the apparent affinity of [3H]flunitrazepam for its binding sites. Stimulation of [3H]flunitrazepam binding by pyrazolopyridines is dependent on the presence of certain anions like… CONTINUE READING
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