Action of protein disulfide isomerase on proinsulin exit from endoplasmic reticulum of pancreatic β-cells.

@article{Rajpal2012ActionOP,
  title={Action of protein disulfide isomerase on proinsulin exit from endoplasmic reticulum of pancreatic β-cells.},
  author={Gautam Rajpal and Irmgard Schuiki and Ming Liu and Allen Volchuk and Peter Arvan},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 1},
  pages={
          43-7
        }
}
For insulin synthesis, the proinsulin precursor is translated at the endoplasmic reticulum (ER), folds to include its three native disulfide bonds, and is exported to secretory granules for processing and secretion. Protein disulfide isomerase (PDI) has long been assumed to assist proinsulin in this process. Herein we have examined the effect of PDI knockdown (PDI-KD) in β-cells. The data establish that upon PDI-KD, oxidation of proinsulin to form native disulfide bonds is unimpaired and in… CONTINUE READING

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