Action of progesterone receptor modulators on uterine leiomyomas.

@article{Ohara2008ActionOP,
  title={Action of progesterone receptor modulators on uterine leiomyomas.},
  author={Noriyuki Ohara},
  journal={Clinical and experimental obstetrics & gynecology},
  year={2008},
  volume={35 3},
  pages={
          165-6
        }
}
  • Noriyuki Ohara
  • Published in Clinical and experimental obstetrics & gynecology 2008
Novel progesterone receptor modulators (PRMs) have recently been demonstrated to be effective in the treatment of patients with symptomatic uterine leiomyomata. PRMs are shown to reduce leiomyoma size and improve leiomyoma-associated symptoms. However, the precise mechanisms underlying the action of PRMs remain to be elucidated. My co-workers and I have investigated in vitro action of PRMs in cultured leiomyoma cells and revealed that PRMs inhibit cell proliferation and induce apoptosis of… CONTINUE READING

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