Corpus ID: 23269341

Action of platelet-activating factor (PAF) antagonists on the bronchopulmonary effects of PAF in the guinea-pig.

@article{Pons1989ActionOP,
  title={Action of platelet-activating factor (PAF) antagonists on the bronchopulmonary effects of PAF in the guinea-pig.},
  author={F. Pons and C. Touvay and V. Lejeune and C. Carr{\'e} and B. Vilain and C. Broquet and J. Mencia-Huerta and P. Braquet},
  journal={Journal of lipid mediators},
  year={1989},
  volume={1 6},
  pages={
          329-40
        }
}
Intravenous injection of BN 52021 in anesthetized guinea-pigs, 5 min before challenge, inhibited in a dose-dependent fashion with an IC50 of 0.90 mg/kg the bronchoconstriction induced by PAF (60 ng/kg i.v.). However, BN 52021 did not prevent the leukopenia following PAF injection but significantly inhibited the thrombocytopenia induced by PAF. The dioxolan compound, BN 52111, dose-dependently reduced the bronchoconstriction (IC50 = 0.27 mg/kg) and at doses higher than 1 mg/kg partially… Expand
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