Action of mycosubtilin on erythrocytes and artificial membranes.


Mycosubtilin has a strong lytic action upon erythrocytes. The haemolytic effect of the antibiotic is inhibited by free cholesterol as well as cholesterol included in liposomes of phosphatidylcholine-cholesterol. The antibiotic binding on artificial membranes was studied with radioactive bilayer vesicles of dipalmitoylphosphatidylcholine (DPPC), and DPPC-cholesterol:mycosubtilin destroyed both kinds of vesicles. The inhibition of the haemolytic effect of mycosubtilin by liposomes is a result of an interaction which diminishes the concentration of free cholesterol.

Cite this paper

@article{Besson1989ActionOM, title={Action of mycosubtilin on erythrocytes and artificial membranes.}, author={Françoise Besson and Micka{\"{e}l Quentin and Gurvan Michel}, journal={Microbios}, year={1989}, volume={59 240-241}, pages={137-43} }