Action of metyrapone and tetracosactrin to modify cisplatin-induced acute and delayed emesis in the ferret.

@article{Sam2003ActionOM,
  title={Action of metyrapone and tetracosactrin to modify cisplatin-induced acute and delayed emesis in the ferret.},
  author={Tasia S W Sam and Kelvin K. Kan and Man P. Ngan and John A Rudd and John Hok Keung Yeung},
  journal={European journal of pharmacology},
  year={2003},
  volume={466 1-2},
  pages={163-8}
}
Cisplatin 5 mg/kg, i.p., induced an acute (day 1) and delayed (days 2 and 3) emetic response in the ferret that was used to investigate the potential anti-emetic activity of metyrapone and tetracosactrin and their potential interaction. The 11beta-hydroxylase enzymes inhibitor metyrapone 10-30 mg/kg, i.p., dose dependently potentiated the acute cisplatin-induce retching+vomiting response by up to 219% at the highest dose (P<0.001) but failed to affect significantly delayed emesis (P>0.05). The… CONTINUE READING