Action of metiamide on the lower esophageal sphincter.

  title={Action of metiamide on the lower esophageal sphincter.},
  author={Sidney J. Cohen and William J. Jr. Snape},
  volume={69 4},
The action of metiamide, an H2 antagonist, was tested for its effect upon lower esophageal sphincter (LES) function in the anesthetized opossum. Intravenous infusions of metiamide gave a dose-related increase in LES pressure. A maximum increase in pressure of 17 mm Hg was attained at 2.0 mg per kg-hr of metiamide. This dose of metiamide abolished acid secretion in response to gastrin I, but augmented the maximal LES response to this hormone. Studies in vitro showed that metiamide augmented the… CONTINUE READING