Action of clonidine on the baroreceptor pathway and medullary sites mediating vagal bradycardia.

@article{Laubie1976ActionOC,
  title={Action of clonidine on the baroreceptor pathway and medullary sites mediating vagal bradycardia.},
  author={Michel Laubie and H{\'e}l{\`e}ne Schmitt and M. Drouillat},
  journal={European journal of pharmacology},
  year={1976},
  volume={38 2},
  pages={293-303}
}
In anaesthetized dogs, clonidine (10 mug/kg i.v.) increased the spontaneous firing of the carotid sinus nerve and decreased blood pressure and heart rate. After transection of the spinal cord, clonidine decreased heart rate and this bradycardia was abolished by selective baroreceptor denervation. Clonidine (1 mug/kg) injected into the vertebral artery of anaesthetized dogs, pretreated with a beta-adrenoceptor blocking agent (S 2395: 50 mug/kg i.v.) potentiated the bradycardia induced by… CONTINUE READING