Action of clonazepam and clorazepate on cortical self-sustained after-discharges in the rat.


Self-sustained after-discharges (SSADs) induced by electric stimulation of the sensorimotor cortex in rats exhibited under control conditions a significant progressive prolongation with repeated stimulations. Clonazepam not only blocked this increase in duration but it suppressed and/or abolished SSADs in a dose-dependent manner. Clorazepate in the lowest… (More)


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