Action of a novel pyrrolo[1,2-c][1.3]benzodiazepine on the viability of Jurkat and neuronal/glial cells.

@article{Rotas2005ActionOA,
  title={Action of a novel pyrrolo[1,2-c][1.3]benzodiazepine on the viability of Jurkat and neuronal/glial cells.},
  author={Georgios Rotas and Ketevan Natchkebia and Nino Natsvlishvili and Merab Kekelidze and Athanasios C. Kimbaris and George I Varvounis and David G. Mikeladze},
  journal={Bioorganic & medicinal chemistry letters},
  year={2005},
  volume={15 13},
  pages={3220-3}
}
We have designed and synthesized several structural isomers of anthramycin (heterocycles 2, 3, 5, 6, and 8) and found that, in particular, pyrrolobenzodiazepine 8 induces DNA cleavage and formation of small fragments of DNA. The cytotoxic effects of 8 were manifested with both non-transformed primary neuronal/glial cells and transformed Jurkat cells. The… CONTINUE READING