Action of RH 5849, a non-steroidal ecdysteroid mimic on Plodia interpunctella (Hübner) in vivo and in vitro.

@article{Silhacek1990ActionOR,
  title={Action of RH 5849, a non-steroidal ecdysteroid mimic on Plodia interpunctella (H{\"u}bner) in vivo and in vitro.},
  author={D. L. Silhacek and H. Oberlander and P. Porcheron},
  journal={Archives of Insect Biochemistry and Physiology},
  year={1990},
  volume={15},
  pages={201-212}
}
We have examined the effects of RH 5849, a non-steroidal ecdysteroid mimic, on the growth and development of Plodia interpunctella. When RH 5849 was administered in the diet, larval growth was inhibited in a dose-dependent manner, while concentrations of 15 ppm and greater were highly toxic. However, the deleterious effects of RH 5849 could be prevented, except at very high concentrations of RH 5849, by the simultaneous administration of the juvenile hormone mimic methoprene. Larvae… Expand
Action of the nonsteroidal ecdysteroid mimic RH 5849 on larval development and adult reproduction of insects of different orders.
Summary Toxicity assays with RH 5849, a nonsteroidal ecdysteroid agonist, indicated a high effectiveness in larval Lepidoptera Spodoptera exempta and Spodoptera littoralis and larvae of theExpand
Effects of the ecdysteroid agonists RH 5849 an RH 5992, alone and in combination with a juvenile hormone analogue, pyriproxyfen, on larvae of Spodoptera exigua
Biological activity assays with RH 5849 and RH 5992 indicated that both compounds affected growth and development of last‐instar larvae of Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae) in aExpand
Differential effects of nonsteroidal ecdysteroid agonists in coleoptera and lepidoptera: Analysis of evagination and receptor binding in imaginal discs
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The results suggest that the specific activity and insect selectivity of the nonsteroidal agonists, especially the high toxicity of tebufenozide for Lepidoptera and the nonsusceptibility of Coleoptera, is related to selective binding on the EcRs. Expand
Interactions of ecdysteroid and juvenoid agonists in Plodia interpunctella (Hübner)
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Results suggest that the pupae respond to RH-5992 in a manner similar to larvae, however, the effects are not expressed overtly and are camouflaged by the pharmacological effects. Expand
Molecular analysis of the mode of action of RH-5992, a lepidopteran-specific, non-steroidal ecdysteroid agonist
TLDR
In vivo and transient in vitro treatment with RH-5992 prevented DDC expression for up to 48 h after the removal of the compound, which mimics the action of 20E on the expression of these 3 genes, but its effects persist in the tissue much longer than 20E. Expand
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Differences in the protein pattern of the cuticle between treated vs. untreated 6th instar larvae indicated that in the newly induced larval cuticle some proteins were missing or expressed with less intensity, which is suggested as a cause of unsuccessful pupation in the treatment. Expand
Juvenilizing effect of ecdysone mimic RH 5849 inGalleria mellonella larvae
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The effect of RH 5849 on the developmental programme in G. mellonella is mediated by the corpora allata, and simultaneous application ofRH 5849 and FMev, a potent inhibitor of JH synthesis, to young final instar larvae lowered the incidence of perfect supernumerary larval moults. Expand
Effects of a nonsteroidal ecdysone agonist, tebufenozide, on host/parasitoid interactions
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Tebufenozide stimulated significant growth in both testes of post-diapausing codling moth larvae and a dormant Ascogaster larva in its overwintering host's hemocoel and benefited the rearing of this eulophid by maintaining the host in the susceptible larval stage and preventing the host larva from spinning a cocoon. Expand
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RH 5849 and its analogs are relatively persistent ecdysone agonists that halt feeding in larval lepidoptera by forcing an ultimately lethal, developmentally premature molt. Expand
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The moulting hormone activity of 13 ecdysteroids has been determined using a housefly ligature bioassay and the effects on fly development of 11 of these when incorporated in a defined diet have beenExpand
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TLDR
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Autocrine and paracrine secretions of ecdysteroids could play a role in localized developmental events, more difficult to control from endocrine glands possibly mitosis, meiosis, reprogramming, regeneration or early steps of embryogenesis. Expand
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TLDR
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