Action of 2',2'-difluorodeoxycytidine on DNA synthesis.

  title={Action of 2',2'-difluorodeoxycytidine on DNA synthesis.},
  author={Pochi Huang and Sherri Chubb and Lary W Hertel and Gerald B. Grindey and William Plunkett},
  journal={Cancer research},
  volume={51 22},
The action of the new deoxycytidine analogue 2',2'-difluorodeoxycytidine (dFdC) on DNA synthesis was investigated in whole cells and in vitro assay systems with purified DNA polymerases. DNA synthesis in human lymphoblastoid CEM cells was inhibited by dFdC in a concentration-dependent manner that could not be reversed by exogenous deoxynucleosides. The… CONTINUE READING