Action Potentials Recorded from Inside a Nerve Fibre

  title={Action Potentials Recorded from Inside a Nerve Fibre},
  author={Alan Lloyd Hodgkin and Andrew Fielding Huxley},
NERVOUS messages are invariably associated with an electrical change known as the action potential. This potential is generally believed to arise at a membrane which is situated between the axoplasm and the external medium. If this theory is correct, it should be possible to record the action potential between an electrode inside a nerve fibre and the conducting fluid outside it. Most nerve fibres are too small for this to be tested directly, but we have recently succeeded in inserting micro… Expand
Physics of nerve processes
Since 1938 investigations have been made on single nerve fibres and similar material to determine the electrical properties of their surface membrane, which is the structure primarily concerned inExpand
From overshoot to voltage clamp
  • A. Huxley
  • Medicine, Materials Science
  • Trends in Neurosciences
  • 2002
This article summarizes speculations about the mechanism by which ions cross the membrane and how the action potential is generated about the current-voltage relations of the nerve membrane. Expand
Impulses in Nerve and Muscle Cells
This chapter reviews the properties of the electric field, electric current, and membrane capacitance that are needed to understand the propagation of the nerve- or muscle-cell action potentials. TheExpand
Studies on Impulse Conduction of Nerve Fibers
Excitation of nerve fibers is conducted as an electrical impulse, namely, the pulse of action current generated on the basis of the conformational change of ionic channels. As early as in theExpand
Membrane Potential and Action Potential
The communication of information in the nervous system depends upon the presence of a difference in the electrical charge between inside and outside of neurons and neuronal processes. This differenceExpand
The Properties of Insect Axons
This chapter describes the nervous system and nerve activity of insects and the development of the capillary microelectrode made it possible to record membrane resting and action potentials from a wide variety of excitable tissues. Expand
  • A. Huxley
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • 1959
There are several different ways in which the electric activity of a nerve fiber depends on movements of inorganic ions, including in the maintenance of the resting potential, which Bernstein (1902) suggested was a concentration potential. Expand
Toward a Minimal Artificial Axon.
The system is minimal in that it is demonstrated that one kind of ion channel and correspondingly a gradient of only one ionic species is sufficient to generate an excitable system which shows amplification and threshold behavior. Expand
MEMBRANE POTENTIAL Membrane Potential Is Generated by the Differential Distribution of Ions
  • 2014
The communication of information between neurons and between neurons and muscles or peripheral organs requires that signals travel over considerable distances. A number of notable scientists haveExpand
Generation and propagation of the action potential.
This chapter is a review of the action potential and its relationship to the signals that are studied in clinical neurophysiology, and mechanisms underlying propagation action potentials within the nervous system are examined. Expand