Action Potentials Recorded from Inside a Nerve Fibre

  title={Action Potentials Recorded from Inside a Nerve Fibre},
  author={Alan Lloyd Hodgkin and Andrew Fielding Huxley},
NERVOUS messages are invariably associated with an electrical change known as the action potential. This potential is generally believed to arise at a membrane which is situated between the axoplasm and the external medium. If this theory is correct, it should be possible to record the action potential between an electrode inside a nerve fibre and the conducting fluid outside it. Most nerve fibres are too small for this to be tested directly, but we have recently succeeded in inserting micro… 

Physics of nerve processes

In vertebrate nerve fibres that conduct impulses at high speed the process for the generation of the action potential occurs in restricted regions separated by lengths of fibre which serve as cable conductors and which have a thick layer of insulating material at their surface.

From overshoot to voltage clamp

Impulses in Nerve and Muscle Cells

The Hodgkin–Huxley model for the current through sodium and potassium ion channels is analyzed in detail and the differences between propagation along unmyelinated and myelinated axons are explored.

Studies on Impulse Conduction of Nerve Fibers

The former phenomenon shows that the cut end of nerve fibers is electrically negative to the intact region of nerve fiber, and the latter shows that in the excited point of the nerve fibers occurs a negative electrical change, which neutralized the negative injury current.


  • A. Huxley
  • Biology
    Annals of the New York Academy of Sciences
  • 1959
There are several different ways in which the electric activity of a nerve fiber depends on movements of inorganic ions, including in the maintenance of the resting potential, which Bernstein (1902) suggested was a concentration potential.

Toward a Minimal Artificial Axon.

The system is minimal in that it is demonstrated that one kind of ion channel and correspondingly a gradient of only one ionic species is sufficient to generate an excitable system which shows amplification and threshold behavior.

Generation and propagation of the action potential.

MEMBRANE POTENTIAL Membrane Potential Is Generated by the Differential Distribution of Ions

  • Biology
  • 2014
This chapter considers the cellular mechanisms by which neurons and axons generate a resting membrane potential and how this membrane potential briefl y is disrupted for the purpose of propagation of an electrical signal, the action potential.