Actinomycin D suppresses the protective effect of dexamethasone in rats affected by global cerebral ischemia.

@article{Tsaki1985ActinomycinDS,
  title={Actinomycin D suppresses the protective effect of dexamethasone in rats affected by global cerebral ischemia.},
  author={Arp{\'a}d T{\'o}saki and M{\'a}ty{\'a}s Koltai and Ferenc Jo{\'o} and Gail Dodge Ian Balitsky Charles I. Sukenik John Adam and P{\'e}ter Szerdahelyi and Istv{\'a}n Lepr{\'a}n and Istv{\'a}n Tak{\'a}ts and Laszlo Szekeres},
  journal={Stroke},
  year={1985},
  volume={16 3},
  pages={501-5}
}
Simultaneous occlusion of both common carotid arteries in female Sprague-Dawley CFY rats produced characteristic symptoms of global cerebral ischemia, such as staggering, circling, convulsions, followed by coma and death. A close correlation existed among these symptoms and the elevation of water and Na+ content, appearing at the stage of staggering; Evans blue extravasation and diminution of K+ content, detected at circling; and the increase in Ca2+ content in the total brain tissue… CONTINUE READING

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