• Chemistry, Medicine
  • Published in
    Journal of molecular…
  • DOI:10.1002/jmr.524

Actinomycin D binding to unstructured, single-stranded DNA.

  title={Actinomycin D binding to unstructured, single-stranded DNA.},
  author={H Yoo and Randolph L. Rill},
  journal={Journal of molecular recognition : JMR},
  volume={14 3},
Actinomycin D is an anticancer antibiotic best know for inhibiting transcription by binding double-stranded DNA. Tight, sequence selective binding of actinomycin to single-stranded DNA is also known, however, and is implicated in biological activities including inhibition of (-) strand transfer by HIV reverse transcriptase. Oligonucleotide d(GTTAACCATAG) is one of the rare single-stranded DNAs that lack GC steps yet have high affinity for actinomycin. Oligonucleotide sequence and length… CONTINUE READING