Actinomycin-D: Effects on Memory at Different Times after Training

@article{Squire1970ActinomycinDEO,
  title={Actinomycin-D: Effects on Memory at Different Times after Training},
  author={Larry R Squire and Samuel H. Barondes},
  journal={Nature},
  year={1970},
  volume={225},
  pages={649-650}
}
INHIBITORS of macromolecular synthesis have been used extensively for studies of memory storage. The amnesic effects of two inhibitors of protein synthesis, acetoxy-cycloheximide and cycloheximide, have been attributed to specific interference with the synthesis of protein required for formation of long-term memory1–4. The effects of actinomycin-D, an inhibitor of DNA-dependent RNA synthesis, have been particularly difficult to interpret because doses sufficient to produce marked inhibition of… CONTINUE READING
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