Actinomycin Biosynthesis


The inhibitory effect of methylprolines on actinomycin biosynthesis by Streptomyces antibioticus was studied; the order of effectiveness was 3>4>5-methylDL-proline. Cis-3-methyl-DL-proline was 14 times more active than the trans isomer. It was also found that 4and, possibly, 5-methylproline were incorporated into the actinomycin molecule. When 4… (More)


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