Actinobacillus actinomycetemcomitans lipopolysaccharide-mediated experimental bone loss model for aggressive periodontitis.

@article{Rogers2007ActinobacillusAL,
  title={Actinobacillus actinomycetemcomitans lipopolysaccharide-mediated experimental bone loss model for aggressive periodontitis.},
  author={Jill E. Rogers and Fei Li and Derek D. Coatney and C. Avignone Rossa and Paul M. Bronson and Jaclynn M Krieder and William V Giannobile and Keith Lough Kirkwood},
  journal={Journal of periodontology},
  year={2007},
  volume={78 3},
  pages={550-8}
}
BACKGROUND Bacterial constituents, such as Gram-negative derived lipopolysaccharide (LPS), can initiate inflammatory bone loss through induction of host-derived inflammatory cytokines. The aim of this study was to establish a model of aggressive inflammatory alveolar bone loss in rats using LPS derived from the periodontal pathogen Actinobacillus actinomycetemcomitans. METHODS Eighteen female Sprague-Dawley rats were divided into LPS test (N = 12) and saline control (N = 6) groups. All… CONTINUE READING

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