Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer.


BACKGROUND & AIMS Enhanced motility of cancer cells by remodeling of the actin cytoskeleton seems crucial in the process of cancer invasion and metastasis. We previously identified an actin-binding protein, actinin-4, as a new biomarker of cancer invasion and an indicator of prognosis for patients with breast cancer. However, its involvement in the… (More)


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