Actinin-4 in keratinocytes regulates motility via an effect on lamellipodia stability and matrix adhesions.


During wound repair, epidermal cells at the edge of an injury establish front-rear polarity through orchestrated changes in their cytoskeleton and adhesion structures. The polarity and directed migration of such cells is determined by the assembly, extension, and stabilization of a lamellipodium. Actinin-4 associates with lamellipodia and has been… (More)
DOI: 10.1096/fj.12-217406


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