Actinic keratosis

  title={Actinic keratosis},
  author={R Rossi and Moira Mori and Torello M Lotti},
  journal={International Journal of Dermatology},
Actinic keratoses (AKs) are extremely common skin neoplasms and represent a significant part of a dermatologist’s practice all over the world. In the USA, they represent the third most frequent reason for consulting a dermatologist. 1 In Australia, the prevalence has been estimated to be 40–50% of the population aged 40 years and above. 2 Similar data have been found in Italy according to our experience. Individual patients may have single or multiple lesions, but the average number of AKs per… 
Current perspective on actinic keratosis: a review
Improved agreement among clinicians on AK definition may improve management, and treatments should aim to decrease the risk of KC or facilitate KC diagnosis by reducing the potential for misidentification created when a KC appears in a field of AKs.
Actinic keratosis as a marker of field cancerization in excision specimens of cutaneous malignancies.
In this study, microscopically identified actinic keratoses (AKs) were used as markers of field cancerization in all excision specimens of squamous cell carcinomas, basal cell carcinoma, and malignant melanomas received by this institution's dermatopathology department over a 3- to 6-month period.
Actinic Neoplasia Syndrome and an Update on the Epidemiology of Basal Cell Carcinoma, Squamous Cell Carcinoma, and Actinic Keratosis
An overview of the epidemiology of basal cell carcinomas and squamous cell carcinoma, as well as actinic keratosis, another exceedingly common consequence of ultraviolet radiation, is provided.
Swiss clinical practice guidelines on field cancerization of the skin.
The Swiss Registry of Actinic Keratosis Treatment (REAKT) Working Group has developed clinical practice guidelines for the treatment of field cancerization in patients who present with AK, and these guidelines are intended to serve as a resource for physicians as to the most appropriate treatment and management.
Oral acetylsalicylic acid and prevalence of actinic keratosis.
The regular use of oral acetylsalicylic acid for more than six months was associated to a lower prevalence of actinic keratosis, especially facial and erythematous ones.
The Relapse rate in patients with actinic keratosis treated with diclofenac sodium 3% gel
In this clinical trial topical therapy with diclofenac gel was demonstrated to be safe and effective overall for the treatment of actinic keratosis.
Clinical, dermoscopic and immunohistochemical assessment of actinic keratoses and evaluation of the effectiveness of diclofenac therapy with immunohistochemical analysis
Diclofenac gel was found to be effective in AK, including the hyperkeratotic type, and anti-proliferative effects of dicl ofenac were demonstrated by decreased Ki-67 and p63 expression levels.
Assessment of BCL-2 expression in actinic keratosis, keratoacanthoma and seborrheic keratosis cases
Aim: One of the main functions of apoptosis is the elimination of cells with damaged DNA, including premalignant cells in skin. Apoptosis is regulated by the balance between antiapoptotic and
Actinic keratosis: correlation between clinical and histological classification systems
There are several clinical and histological classification systems for grading actinic keratosis (AK) lesions. The Olsen clinical classification scheme grades AK lesions according to their thickness
The clinical course of actinic keratosis correlates with underlying molecular mechanisms
The majority of AKs regress or persist, but some progress to squamous cell carcinomas, and biomarkers associated with their persistence, progression and regression have not been characterized.