Acting via a cell surface receptor, thyroid hormone is a growth factor for glioma cells.

  title={Acting via a cell surface receptor, thyroid hormone is a growth factor for glioma cells.},
  author={Faith B. Davis and Heng-Yuan Tang and A G Shih and Travis Keating and Lawrence S Lansing and Aleck H Hercbergs and Robert A. Fenstermaker and Ahmed Mousa and Shaker A. Mousa and Paul J. Davis and Hung-Yun Lin},
  journal={Cancer research},
  volume={66 14},
Recent evidence suggests that the thyroid hormone L-thyroxine (T4) stimulates growth of cancer cells via a plasma membrane receptor on integrin alphaVbeta3. The contribution of this recently described receptor for thyroid hormone and receptor-based stimulation of cellular mitogen-activated protein kinase [MAPK; extracellular signal-regulated kinase 1/2 (ERK1/2)] activity, to enhancement of cell proliferation by thyroid hormone was quantitated functionally and by immunologic means in three… CONTINUE READING


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