Actin with tumor-related mutation is antimorphic in Drosophila muscle: two distinct modes of myofibrillar disruption by antimorphic actins.

@article{Sakai1990ActinWT,
  title={Actin with tumor-related mutation is antimorphic in Drosophila muscle: two distinct modes of myofibrillar disruption by antimorphic actins.},
  author={Yoshihisa Sakai and Haruko Okamoto and Kaname Mogami and Tomoko Yamada and Yasuo Hotta},
  journal={Journal of biochemistry},
  year={1990},
  volume={107 3},
  pages={499-505}
}
A mutant beta-actin with an amino acid substitution from Gly-245 to Asp has been shown to be related to tumorigenic transformation of a human fibroblast cell line (Leavitt, J. et al. (1987) Mol. Cell. Biol. 7, 2467-2476). To examine the effects of this mutation, we artificially introduced the same amino acid change into the Act88F actin gene of Drosophila… CONTINUE READING