Actin stress in cell reprogramming.

  title={Actin stress in cell reprogramming.},
  author={Jun Guo and Yuexiu Wang and Frederick Sachs and Fanjie Meng},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 49},
Cell mechanics plays a role in stem cell reprogramming and differentiation. To understand this process better, we created a genetically encoded optical probe, named actin-cpstFRET-actin (AcpA), to report forces in actin in living cells in real time. We showed that stemness was associated with increased force in actin. We reprogrammed HEK-293 cells into stem-like cells using no transcription factors but simply by softening the substrate. However, Madin-Darby canine kidney (MDCK) cell… CONTINUE READING
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