Actin reorganization in airway smooth muscle cells involves Gq and Gi-2 activation of Rho.

@article{Hirshman1999ActinRI,
  title={Actin reorganization in airway smooth muscle cells involves Gq and Gi-2 activation of Rho.},
  author={Carol A. Hirshman and Charles W. Emala},
  journal={The American journal of physiology},
  year={1999},
  volume={277 3 Pt 1},
  pages={L653-61}
}
Extracellular stimuli induce cytoskeleton reorganization (stress-fiber formation) in cells and Ca2+ sensitization in intact smooth muscle preparations by activating signaling pathways that involve Rho proteins, a subfamily of the Ras superfamily of monomeric G proteins. In airway smooth muscle, the agonists responsible for cytoskeletal reorganization via actin polymerization are poorly understood. Carbachol-, lysophosphatidic acid (LPA)-, and endothelin-1-induced increases in filamentous actin… CONTINUE READING