Actin redistribution underlies the sparing effect of mild hypothermia on dendritic spine morphology after in vitro ischemia.

@article{Gisselsson2005ActinRU,
  title={Actin redistribution underlies the sparing effect of mild hypothermia on dendritic spine morphology after in vitro ischemia.},
  author={L Lennart Gisselsson and Andrew Matus and Tadeusz Wieloch},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2005},
  volume={25 10},
  pages={1346-55}
}
Brain hypothermia is at present the most effective neuroprotective treatment against brain ischemia in man. Ischemia induces a redistribution of proteins involved in synaptic functions, which is markedly diminished by therapeutic hypothermia (33 degrees C). Dendritic spines at excitatory synapses are motile and show both shape changes and rearrangement of synaptic proteins as a consequence of neuronal activity. We investigated the effect of reduced temperature (33 degrees C and 27 degrees C… CONTINUE READING

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