Actin realignment and cofilin regulation are essential for barrier integrity during shear stress.

@article{Slee2013ActinRA,
  title={Actin realignment and cofilin regulation are essential for barrier integrity during shear stress.},
  author={Joshua B. Slee and Linda J. Lowe-Krentz},
  journal={Journal of cellular biochemistry},
  year={2013},
  volume={114 4},
  pages={782-95}
}
Vascular endothelial cells and their actin microfilaments align in the direction of fluid shear stress (FSS) in vitro and in vivo. To determine whether cofilin, an actin severing protein, is required in this process, the levels of phospho-cofilin (serine-3) were evaluated in cells exposed to FSS. Phospho-cofilin levels decreased in the cytoplasm and increased in the nucleus during FSS exposure. This was accompanied by increased nuclear staining for activated LIMK, a cofilin kinase. Blocking… CONTINUE READING
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