Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability

@inproceedings{Santos2016ActinPA,
  title={Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability},
  author={Lu{\'i}s Carlos Aguiar Santos and David A.D. Blair and Sudha Kumari and Michael Cammer and Thomas Iskratsch and Olivier Herbin and Konstantina Alexandropoulos and Michael L. Dustin and Michael P Sheetz},
  booktitle={Immunology and cell biology},
  year={2016}
}
The immunological synapse formed between a T-cell and an antigen-presenting cell is important for cell-cell communication during T-cell-mediated immune responses. Immunological synapse formation begins with stimulation of the T-cell receptor (TCR). TCR microclusters are assembled and transported to the center of the immunological synapse in an actin polymerization-dependent process. However, the physical link between TCR and actin remains elusive. Here we show that lymphocyte-specific Crk… CONTINUE READING
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