Actin polymerization and depolymerization during apoptosis in HL-60 cells.

@article{Levee1996ActinPA,
  title={Actin polymerization and depolymerization during apoptosis in HL-60 cells.},
  author={Minette G. Levee and Milena I. Dabrowska and Joseph L. Lelli and Daniel B. Hinshaw},
  journal={The American journal of physiology},
  year={1996},
  volume={271 6 Pt 1},
  pages={
          C1981-92
        }
}
Little is known about the biochemical "machinery" responsible for the morphological features of apoptosis, although the cytoskeleton is presumed to be involved. Using flow cytometry, polyacrylamide gel electrophoresis, and fluorescence microscopy, we show that apoptosis induced by ultraviolet (UV) irradiation or 80 micrograms/ml etoposide correlates with early transient polymerization and later depolymerization of filamentous (F)-actin and dramatic changes in visible microfilament organization… CONTINUE READING
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