Actin mediates secretory immunoglobulin A transport: effect of ethanol.

@article{Diebel2002ActinMS,
  title={Actin mediates secretory immunoglobulin A transport: effect of ethanol.},
  author={Lawrence N. Diebel and David M Liberati and Manmit S Saini and Scott A. Dulchavsky and Clement A. Diglio and William J. Brown},
  journal={The American surgeon},
  year={2002},
  volume={68 9},
  pages={769-74; discussion 774-5}
}
Secretory immunoglobulin A (IgA) is the principle antibody protecting against pathogens at mucosal sites. Ethanol (EtOH) exposure is related to adverse effects on the enterocyte cytoskeleton. The aim of this study was to assess the role of normal cytoskeletal function on IgA transcytosis and its modulation by EtOH by studying Madin-Darby canine kidney (MDCK) cells transfected with the polyimmunoglobulin receptor. MDCK cells were grown as confluent monolayers and treated with 5 per cent EtOH… CONTINUE READING