Actin-mediated gene expression in neurons: the MRTF-SRF connection

  title={Actin-mediated gene expression in neurons: the MRTF-SRF connection},
  author={Bernd Kn{\"o}ll},
  booktitle={Biological chemistry},
  • B. Knöll
  • Published in Biological chemistry 1 June 2010
  • Biology
Abstract The traditional view of cellular actin is a rather autarkic cytoskeletal framework function confined to the cytoplasm. However, there is now evidence that alterations in actin dynamics are sensed by the nucleus and subsequently modulate gene expression. In communicating with the nucleus, cytoplasmic, and most likely also nucleus-resident actin, provides a further (gene) regulatory loop to cell motility. A transcription module composed of MRTF (myocardin-related transcription factor… 

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