Actin mRNA localizes in the absence of protein synthesis

  title={Actin mRNA localizes in the absence of protein synthesis},
  author={Cynthia L Sundell and Robert H Singer},
  journal={The Journal of Cell Biology},
  pages={2397 - 2403}
Actin mRNA is localized in chicken embryo fibroblasts to the distal regions of leading lamellae, but not within the ruffling edges. In this investigation we have addressed the role of actin translation in this process. The translocation of actin mRNA to the cell periphery was studied by monitoring the distribution of actin mRNA in cells during spreading. Within 90 min, actin mRNA moved from a perinuclear to a peripheral distribution. Formation of lamellipodia preceded actin mRNA localization… CONTINUE READING

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