Actin in the nucleus: what form and what for?

  title={Actin in the nucleus: what form and what for?},
  author={Thoru Pederson and Ueli Aebi},
  journal={Journal of structural biology},
  volume={140 1-3},
Actin is an abundant protein in most nonmuscle cells. It has often been observed in isolated nuclei, yet cytoplasmic contamination was of course initially regarded as the most plausible origin. Numerous studies on nuclear actin appeared in the 1970s and 1980s, but the picture remained rather muddy. The viewpoint at that time was that actin-shown to move freely between cytoplasm and nucleus-was a mere "thermodynamic wanderer," transiently occupying the nucleus. More recently, evidence has been… CONTINUE READING

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