Actin filaments function as a tension sensor by tension-dependent binding of cofilin to the filament

@inproceedings{Hayakawa2011ActinFF,
  title={Actin filaments function as a tension sensor by tension-dependent binding of cofilin to the filament},
  author={Kimihide Hayakawa and Hitoshi Tatsumi and Masahiro Sokabe},
  booktitle={The Journal of cell biology},
  year={2011}
}
Intracellular and extracellular mechanical forces affect the structure and dynamics of the actin cytoskeleton. However, the underlying molecular and biophysical mechanisms, including how mechanical forces are sensed, are largely unknown. Actin-depolymerizing factor/cofilin proteins are actin-modulating proteins that are ubiquitously distributed in eukaryotes, and they are the most likely candidate as proteins to drive stress fiber disassembly in response to changes in tension in the fiber. In… CONTINUE READING
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