Actin dynamics modulate mechanosensitive immobilization of E-cadherin at adherens junctions

@article{Engl2014ActinDM,
  title={Actin dynamics modulate mechanosensitive immobilization of E-cadherin at adherens junctions},
  author={Wilfried C Engl and Bakya Arasi and Lai Lai Yap and Jean Paul Thiery and Virgile Viasnoff},
  journal={Nature Cell Biology},
  year={2014},
  volume={16},
  pages={584-591}
}
Mechanical stress is increasingly being shown to be a potent modulator of cell–cell junctional morphologies in developmental and homeostatic processes. Intercellular force sensing is thus expected to be an important regulator of cell signalling and tissue integrity. In particular, the interplay between myosin contractility, actin dynamics and E-cadherin recruitment largely remains to be uncovered. We devised a suspended cell doublet assay to quantitatively assess the correlation between myosin… CONTINUE READING
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