Actin dynamics in the contractile ring during cytokinesis in fission yeast

  title={Actin dynamics in the contractile ring during cytokinesis in fission yeast},
  author={Robert J. Pelham and Fred Chang},
Cytokinesis in many eukaryotes requires a contractile ring of actin and myosin that cleaves the cell in two. Little is known about how actin filaments and other components assemble into this ring structure and generate force. Here we show that the contractile ring in the fission yeast Schizosaccharomyces pombe is an active site of actin assembly. This actin polymerization activity requires Arp3, the formin Cdc12, profilin and WASP, but not myosin II or IQGAP proteins. Both newly polymerized… 

Contractile‐ring assembly in fission yeast cytokinesis: Recent advances and new perspectives

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Formins filter modified actin subunits during processive elongation.

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Myosin-II-Dependent Localization and Dynamics of F-Actin during Cytokinesis




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The Arp2/3 complex: a multifunctional actin organizer.

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