Actin dynamics at pointed ends regulates thin filament length in striated muscle

@article{Littlefield2001ActinDA,
  title={Actin dynamics at pointed ends regulates thin filament length in striated muscle},
  author={Ryan S. Littlefield and Angels Almenar-Queralt and Velia M Fowler},
  journal={Nature Cell Biology},
  year={2001},
  volume={3},
  pages={544-551}
}
Regulation of actin dynamics at filament ends determines the organization and turnover of actin cytoskeletal structures. In striated muscle, it is believed that tight capping of the fast-growing (barbed) ends by CapZ and of the slow-growing (pointed) ends by tropomodulin (Tmod) stabilizes the uniform lengths of actin (thin) filaments in myofibrils. Here we demonstrate for the first time that both CapZ and Tmod are dynamic on the basis of the rapid incorporation of microinjected rhodamine… CONTINUE READING
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