Actin dynamics and cofilin-actin rods in alzheimer disease.

  title={Actin dynamics and cofilin-actin rods in alzheimer disease.},
  author={James R. Bamburg and Barbara W. Bernstein},
  volume={73 9},
Cytoskeletal abnormalities and synaptic loss, typical of both familial and sporadic Alzheimer disease (AD), are induced by diverse stresses such as neuroinflammation, oxidative stress, and energetic stress, each of which may be initiated or enhanced by proinflammatory cytokines or amyloid-β (Aβ) peptides. Extracellular Aβ-containing plaques and intracellular phospho-tau-containing neurofibrillary tangles are postmortem pathologies required to confirm AD and have been the focus of most studies… CONTINUE READING
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