Actin disassembles reversibly during electrically induced recycling of synaptic vesicles in cultured neurons.

@article{Bernstein1998ActinDR,
  title={Actin disassembles reversibly during electrically induced recycling of synaptic vesicles in cultured neurons.},
  author={Barbara W. Bernstein and M Dewit and James R. Bamburg},
  journal={Brain research. Molecular brain research},
  year={1998},
  volume={53 1-2},
  pages={236-51}
}
We have studied depolarization-induced regulation of actin assembly in exocytotically active areas of dissociated chick sympathetic neurons. Active areas were identified with the fluorescent dye FM1-43 which labels synaptic vesicles that recycle in these regions. Exocytosis (electrically stimulated) was monitored in real time through depletion of FM1-43 fluorescence. To study depolarization-induced disassembly of actin in the FM1-43-stained regions, the cells were fixed after different periods… CONTINUE READING

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