Actin-depolymerizing factor cofilin-1 is necessary in maintaining mature podocyte architecture.

  title={Actin-depolymerizing factor cofilin-1 is necessary in maintaining mature podocyte architecture.},
  author={Puneet Garg and Rakesh Verma and Leslie Cook and Abdul Soofi and Madhusudan P Venkatareddy and Britta George and Kensaku Mizuno and Christine B. Gurniak and Walter Witke and Lawrence B. Holzman},
  journal={The Journal of biological chemistry},
  volume={285 29},
Actin dynamics determines podocyte morphology during development and in response to podocyte injury and might be necessary for maintaining normal podocyte morphology. Because podocyte intercellular junction receptor Nephrin plays a role in regulating actin dynamics, and given the described role of cofilin in actin filament polymerization and severing, we hypothesized that cofilin-1 activity is regulated by Nephrin and is necessary in normal podocyte actin dynamics. Nephrin activation induced… CONTINUE READING