Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase.

@article{Fan2004ActinDT,
  title={Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase.},
  author={Lingzhi Fan and Caterina Di Ciano-Oliveira and Scott A. Weed and Andrew W. B. Craig and Peter A. Greer and Ori D. Rotstein and Andr{\'a}s Kapus},
  journal={The Biochemical journal},
  year={2004},
  volume={380 Pt 2},
  pages={
          581-91
        }
}
The F-actin-binding protein cortactin is an important regulator of cytoskeletal dynamics, and a prominent target of various tyrosine kinases. Tyrosine phosphorylation of cortactin has been suggested to reduce its F-actin cross-linking capability. In the present study, we investigated whether a reciprocal relationship exists, i.e. whether the polymerization state of actin impacts on the cortactin tyrosine phosphorylation. Actin depolymerization by LB (latrunculin B) induced robust… CONTINUE READING
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