Actin depolymerization drives actomyosin ring contraction during budding yeast cytokinesis.

@article{Pinto2012ActinDD,
  title={Actin depolymerization drives actomyosin ring contraction during budding yeast cytokinesis.},
  author={In{\^e}s Mendes Pinto and Boris Rubinstein and Andrei Kucharavy and Jay R Unruh and Rong Li},
  journal={Developmental cell},
  year={2012},
  volume={22 6},
  pages={1247-60}
}
Actin filaments and myosin II are evolutionarily conserved force-generating components of the contractile ring during cytokinesis. Here we show that in budding yeast, actin filament depolymerization plays a major role in actomyosin ring constriction. Cofilin mutation or chemically stabilizing actin filaments attenuate actomyosin ring constriction. Deletion of myosin II motor domain or the myosin regulatory light chain reduced the contraction rate and also the rate of actin depolymerization in… CONTINUE READING