Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis.

@article{Shen2005ActinDD,
  title={Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis.},
  author={Le Shen and Jerrold R Turner},
  journal={Molecular biology of the cell},
  year={2005},
  volume={16 9},
  pages={
          3919-36
        }
}
The tight junction (TJ) determines epithelial barrier function. Actin depolymerization disrupts TJ structure and barrier function, but the mechanisms of this effect remain poorly understood. The goal of this study was to define these mechanisms. Madin-Darby canine kidney (MDCK) cells expressing enhanced green fluorescent protein-, enhanced yellow fluorescent protein-, or monomeric red fluorescent protein 1-fusion proteins of beta-actin, occludin, claudin-1, ZO-1, clathrin light chain A1, and… CONTINUE READING
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