Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function

  title={Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function},
  author={Christina A. Pacak and Janine M. Preble and Hiroshi Kondo and Peter Seibel and Sidney Levitsky and Pedro J. del Nido and Douglas B. Cowan and James D McCully},
  booktitle={Biology open},
Previously, we have demonstrated that the transplantation of viable, structurally intact, respiration competent mitochondria into the ischemic myocardium during early reperfusion significantly enhanced cardioprotection by decreasing myocellular damage and enhancing functional recovery. Our in vitro and in vivo studies established that autologous mitochondria are internalized into cardiomyocytes following transplantation; however, the mechanism(s) modulating internalization of these organelles… CONTINUE READING
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