Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast

@article{Takizawa1997ActindependentLO,
  title={Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast},
  author={Peter A. Takizawa and Anita Sil and Jason R. Swedlow and Ira Herskowitz and Ronald D. Vale},
  journal={Nature},
  year={1997},
  volume={389},
  pages={90-93}
}
The cytoplasmic localization of messenger RNA creates an asymmetric distribution of proteins that specify cell fate during development in multicellular eukaryotes. The protein Ash1 is a cell-fate determinant in budding yeast which localizes preferentially to the presumptive daughter nucleus, where it inhibits mating-type switching. Here we show that Ash1 mRNA is localized to the distal tip of daughter buds in post-anaphase cells. Three-dimensional imaging reveals that Ash1 mRNA is assembled… CONTINUE READING

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