Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control-directed cell migration.

@article{Ballestrem2000ActindependentLF,
  title={Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control-directed cell migration.},
  author={Christoph Ballestrem and Bernhard Wehrle-Haller and Boris Hinz and Beat Albert Imhof},
  journal={Molecular biology of the cell},
  year={2000},
  volume={11 9},
  pages={
          2999-3012
        }
}
Migrating cells are polarized with a protrusive lamella at the cell front followed by the main cell body and a retractable tail at the rear of the cell. The lamella terminates in ruffling lamellipodia that face the direction of migration. Although the role of actin in the formation of lamellipodia is well established, it remains unclear to what degree microtubules contribute to this process. Herein, we have studied the contribution of microtubules to cell motility by time-lapse video microscopy… CONTINUE READING

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