Actin-dependent activation of ion conductances in bronchial epithelial cells

  title={Actin-dependent activation of ion conductances in bronchial epithelial cells},
  author={Thomas Hug and Thomas Christian Koslowsky and Daniela Ecke and Rainer Greger and Karl Kunzelmann},
  journal={Pfl{\"u}gers Archiv},
Activation of Cl− and K+ channels is necessary to drive ion secretion in epithelia. There is substantial evidence from previous reports that vesicular transport and exocytosis are involved in the regulation of ion channels. In the present study we examined the role of cytoskeletal elements and components of intracellular vesicle transport on ion channel activation in bronchial epithelial cells. To this end, cells were incubated with a number of different compounds which interact with either… CONTINUE READING


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